Endocrine Abstracts

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

Background: Neutrophil gelatinase-associated lipocalin (NGAL) and the Matrix Metaloproteinase-9 (MMP-9) have been considered as important mediators of vascular remodeling and plaque instability. The formation of a complex with NGAL and MMP-9 is crucial for atherotic plaque erosion and thrombus formation. In women with Polycystic Ovary Syndrome (PCOS) the incidence of cardiovascular clinical events is not increased, despite the fact that they display a wide spectrum of risk fac...

Context: The early activation of adrenal zona reticularis, denoted by increased circulating levels of adrenal androgens before the age of eight years in girls is called premature adrenarche (PA), while the concomitant appearance of pubic hair is termed premature pubarche (PP). Girls with PA-PP display an unfavorable metabolic, hormonal and psychologic profile, compared to their normal peers and are also at an increased risk of developing polycystic ovary syndrome (PCO...

ObjectiveThe exact risk of type 2 diabetes in women with polycystic ovary syndrome (PCOS) is unknown. It is also unclear if obesity independently increases the risk in this population. The aim of this study was to systematically review and synthesize the best available evidence regarding the association between PCOS and type 2 diabetes, stratified according to obesity status.MethodsA comprehensive search was ...

Aims: While hormonal assays are commonly used for thyroid function assessment, Doppler sonography provides valuable information on vascularization and blood flow. This study aimed to examine the potential associations between Doppler parameters and clinical characteristics of hypothyroid patients, such as the autoimmune nature of the disease and adequacy of LT4 replacement.Methods: A total of 338 patients with hypothyroidism, primarily caused by autoimmu...

Introduction: Use of supplements (VDS) and vitamin-D measurements have been rising in the recent past globally. Despite increasing intake, our observations reveal that a large percentage of the population remains deficient (VDD). We designed the present real-world study, to address this controversy.Methods: We collected data from patients attending our clinics between March 2014 and December 2022. We recorded our subjects’ gender, age, history of VD...

Introduction: Chronic lymphocytic thyroiditis is an important risk factor for differentiated thyroid cancer (DTC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) seems less clear in that regard. We designed the present study to evaluate that effect in our large patient population. Methods: We recruited subjects operated with total thyroidectomy in 4 sites (USA: 1, Greece: 3) during a period of 14 consecutive years. We gathered dat...

Introduction: Hashimoto’s thyroiditis raises the risk for thyroid cancer (TC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) remains controversial in that regard. We designed the present study to evaluate the effect of preoperative TPO titers in the risk of DTC.Methods: A comprehensive search was conducted in PubMed, CENTRAand Scopus databases in November 2021 for the terms “thyroid cancer” and “TPO” or &...

DM1 constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications and improve the quality of life of patients. These programs provide patients with the necessary knowledge and skills to self-m...

Background: Polycystic ovary syndrome (PCOS) is a complex metabolic disorder and hyperandrogenism and insulin resistance constitute the key players of syndrome pathogenesis. Another emerging important factor of PCOS is low-grade chronic inflammation. The aim of the present study was to investigate white blood cells count (WBC) in PCOS and assess its role as a possible marker of low-grade inflammation.Methods: Anthropometrical, metabolic and hormonal data...